4 Newcastle United Kingdom Get yourself to these

first_img4. Newcastle, United KingdomGet yourself to these Geordie Shores for a cracking night out, great art galleries and brilliant shopping. Newcastle Upon Tyne is a hive of busy nightclubs and live music venues. Whether you prefer high drama at the Theatre Royal or checking out a headline act the O2 Academy, ‘the Toon’ has it all. 3. Nova Scotia, CanadaA province of Canada, Nova Scotia, meaning New Scotland, is a large peninsula off the east coast renowned for natural beauty, especially during autumn when the forests blaze gold and red with the changing colour of the leaves. Get on your bike and cycle across the beautiful landscape, or take to the water for a sea-kayaking tour.Read more: 5 things to ‘fall’ in love with in Canada Looking for affordable accommodation in any of these destinations? Check out Skyscanner’s hotel search and bag a bargain.ReturnOne wayMulti-cityFromAdd nearby airports ToAdd nearby airportsDepart14/08/2019Return21/08/2019Cabin Class & Travellers1 adult, EconomyDirect flights onlySearch flights Map 6. New Corella, PhilippinesIn the province of Davao del Norte, the banana capital of the Philippines, New Corella is the perfect place to get off the tourist trail and live like a local. Go slightly further afield and sail away to Mindanao Island and climb Mount Apo, the Philippines’ highest mountain. 7. New Mexico, United StatesThe ‘Land of Enchantment’, New Mexico in the US Southwest is a melting pot of Spanish, South American and Caribbean culture. Eat some of the tastiest tacos north of the Mexican border in the state capital, Santa Fe, or spot UFOs in Roswell, the supposed-site of a flying saucer crash in 1947. 2. New Hampshire, United StatesNew England’s New Hampshire really does feel like Little Britain, home to cities named Portsmouth, Manchester and Dover. It’s also where the famous Salem witch trials took place in 1692. These days locals are a lot more welcoming, and tourists flock here during ski season to hit the slopes.Read more: World’s weirdest ski resorts 9. New South Wales, AustraliaFind a new lease of life in the south-eastern state of New South Wales. Sail through Sydney Harbour or climb the famous bridge for a new perspective on Australia’s oldest city. If recent New Year festivities haven’t put you off entirely, then check out Hunter Valley where you’ll find some of the county’s finest vineyards and plenty of opportunity to sample some fine Aussie wines.Read more: Australia – in pictures 8. Nuevo León, MexicoNuevo León, or New Leon is home to Mexico’s largest national park, Cumbres de Monterrey where you can scale the canyons and camp in the bottom of the gorges. Satisfy your sweet tooth with a dose of leche quemada, a treat made with caramelised milk and often flavoured with pecans for which the region is famous. 5. New CaledoniaOwned by France, this Pacific Ocean island paradise is made up of one main island, Grand Terre and lots of smaller uninhabited sandbanks. Live the luxury lifestyle and charter a yacht to take you sightseeing and find a secluded sandy beach to sun yourself on. Sticking to a tighter holiday budget? Feast like a king on fresh seafood or French cuisine in Nouméa, the capital, for pennies. Fancy exploring a ‘new’ and exciting destination this year?Get over the holiday hangover and look forward to 2015 with a fresh list of alternative escapes to liven up your travel wish list. From New Zealand to New Caledonia, here are 9 ‘new’ destinations to consider:1. New ZealandThe place to go if you’re looking for an adventure, grab an ice pick and hike across Fox Glacier in the South Island, or head to thrill-seeker central, Queenstown and try a spot of bungee jumping or go for a spin on the shotover jet boat. Make new friends with the Māori, New Zealand’s native people, and learn about their customs and traditions in the North Island.Read more: 10 most awesome adventure activities in Australia and New Zealand Related9 european alternatives to the world’s top travel must-seesFrom island paradises to active volcanoes- you don’t have to travel half-way around the world to complete your travel bucket list.Travel Trends: World’s top destinations for 2015From street food in Seoul to volcano-surfing in Nicaragua, we reveal the hottest destinations and coolest activities for 2015.Ten adventures for 2018Want to know where to go for adventure travel in 2018? Climbing Everest is so last year (and pretty difficult, too). We’ve put together a list of perfectly do-able adventures for 2018, whether you’re a die-hard thrill-seeker or the kind of traveller who loves seeking out the world’s most remote…last_img read more

Now That RightToTry Law Is Enacted Even Supporters Are Wondering If They

first_img Alexion Pharmaceuticals (ALXN) said Monday that its newly approved drug Ultomiris achieved the primary goal of a late-stage clinical trial involving patients with a rare type of kidney disease. Based on the successful outcome of the clinical trial, the Boston-based biotech will file a marketing application with regulators to expand the approved diseases covered by the Ultomiris label. (Feuerstein, 1/28) Stat: Alexion’s Newly Approved Rare-Disease Drug Notches A Clinical Trial Win Patients and family members like Frank and Marilyn [Mongiello] — a half dozen of whom spoke to STAT — described making dozens of unreturned calls to drug makers, outlining plans to pitch the companies on how right to try could be good for business, and even trolling Food and Drug Administration Twitter accounts hoping to drum up some help getting access. Their failures so far underscore just how many questions remain: Did the [right-to-try] law change anything, or did it just give patients false hope? Were the detractors who made such critiques right all along? (Florko, 1/29) Now That Right-To-Try Law Is Enacted, Even Supporters Are Wondering If They Were Sold False Hope As conservatives pushed for the right-to-try legislation, opponents of the bill were vocal in saying that it would give desperate patients false hope. Now, that those patients are trying to get experimental drugs from pharmaceutical companies, they face discouraging obstacles and frustrations. In other pharmaceutical news: Medicare Part D discounts; congressional drug price hearings; an expensive cystic fibrosis treatment; and more. Watch pharmaceutical stocks on Tuesday as the new Congress kicks off its first hearings on drug pricing this year. The two meetings, by the House Oversight and Senate Finance committees, will both focus on the impact of rising drug prices, and lawmakers are expected to make their case for more direct government involvement in pricing decisions for Medicare and allowing Americans to import certain drugs from Canada for personal use. (Darie, 1/28) Bloomberg: Pharma Stocks In Focus As Congress Kicks Off Drug Cost Hearings  In what is being called a novel bid to lower medicine costs, a drug maker has agreed to adjust the discounts that a Medicare Part D plan will receive for a treatment based on how patients respond — and the deal automatically lowers out-of-pocket costs for patients, as well. In this instance, the UPMC Health plan will pay less for an AstraZeneca (AZN) blood thinner known as Brilinta, which is given to patients who suffered a heart attack, if it fails to prevent another attack over 12 months. Conversely, the health plan pays more if Brilinta works. At the same time, the patient copay will drop to $10, from around $45, for a month’s supply, bringing the cost closer to a generic version of a rival medicine. (Silverman, 1/28) Stat: Vertex Faces More Pressure Over Pricing, But One Analyst Expects No Movement  center_img Miami Herald: FDA On Carcinogen NDEA In Valsartan, Losartan, Irbesartan Stat: A Year After Trump Touted Right To Try, Patients Still Aren’t Getting Treatment With blood pressure patients on edge after numerous recalls of valsartan, losartan and irbesartan for too much NDEA, FDA commissioner Scott Gottlieb and Center for Drug Evaluation and Research Director Janet Woodcock issued a lengthy joint statement last week. Impurities in NDEA (N-Nitrosodiethylamine) and NDMA (N-Nitrosodimethylamine) have been classified as “probable human carcinogens,” meaning they cause cancer. (Neal, 1/28) This is part of the KHN Morning Briefing, a summary of health policy coverage from major news organizations. Sign up for an email subscription. As a protracted battle between Vertex Pharmaceuticals (VRTX) and the U.K. drags on over pricing for cystic fibrosis drugs, a coalition of families, patient advocates, academics, and physicians from more than a dozen countries are urging the company to lower its prices and widen access to “desperate patients.” In an open letter to Vertex chief executive Jeffrey Leiden, the ad hoc group praised the company for “inspirational science and dedication,” but also chastised the drug maker for not doing more to ensure its medicines reach every potential patient. (Silverman, 1/28) Stat: AstraZeneca Strikes ‘Novel’ Deal With A Medicare Plan To Lower Patient Costs last_img read more