Clinical trials for SA anti-malaria drug

first_img29 August 2012The development of a single-dose anti-malarial drug by the University of Cape Town (UCT) could help Africa and the rest of the world tackle a disease which claims almost a million lives a year, Minister of Science and Technology Naledi Pandor said on Tuesday.The new molecule, developed by UCT’s Drug Discovery and Development Centre (H3-D), was selected last month by Switzerland’s Medicines for Malaria Venture (MMV) for further development.It will now undergo a lengthy period of clinical trials and has the potential to become a single-dose cure for all strains of malaria and might also be able to block person-to-person transmission of the parasite.Pandor said the compound has already been found to be a complete cure for animals infected by malaria. The department had provided R25-million in funding for the development of the drug.African researchers finding solutionsThe development of the drug has also helped train 10 local scientists and helped cement relations with international partner the MMV, which is based in Switzerland.Pandor lauded the research partnership between the MMV and the H3-D centre and said it was essential to see African researchers involved in finding solutions to African problems.She said South Africa had recently made significant progress in developing the basic sciences that underpin infectious disease research in the fields of immunology, virology, bio-chemistry, microbiology and genetics.With the majority of the more than a billion people infected by communicable diseases located in developing countries, new research into neglected diseases was crucial, Pandor said.The director of H3-D, Kelly Chibale, said the new drug was important, especially as others had proved ineffective in tackling parasites that had become drug-resistant.“When we tested this molecule in animals that are infected with parasites, with a single low dose of this molecule, we could cure the infection completely,” Chibale said.‘A unique research initiative’The H3-D team – with help from the Swiss Tropical and Public Health Institute, Australia’s Centre for Drug Candidate Optimisation and India’s Syngene – spent 18 months developing a candidate molecule suitable for pre-clinical development.Chibale commended the Science and Technology Department for its research chairs initiative, saying his research chair had afforded him the time to put together a team to carry out the research into an anti-malaria drug and was geared to training the next generation of researchers.“This is not something that would have happened if I had been carrying a heavy load of teaching commitments and I think this is something unique and special about this country [the research chairs initiative],” he said.The MMV’s chief scientific officer, Tim Wells, said that if all went well, the drug could expect to hit the market by 2020. He added that the clinical development phase would take around seven years – costing about R20-million a year.He said the aim was to make it available to ordinary Africans, at affordable rates of less than a dollar a dose.Wells added that although a vaccine for African malaria was being developed for 2015, there would still be a need for medication in a drug form.Source: SANews.gov.zalast_img read more

How to Cheat* at LEED for Homes

first_imgThe subject of many of my talks, as well as a chapter in the upcoming green building textbook I am co-authoring is the concept of “Green From the Start.”I realize this isn’t all that original, but it is critically important and is always worth repeating, at least until everyone understands and actually does it – then I suppose we can all shut up and go home.Getting green certification begins with looking at the checklist and planning a design strategy. Sure, you can go the hard route and aim for full credits on every item on the checklist, but for those just trying to dip their toe in the green building pool, this isn’t practical.Instead, pick up as many points as you can by doing the easy stuff. While this isn’t technically cheating, it will feel like it because many of these things are things that quality builders do already.In (roughly) the order that they appear on the LEED checklist, here are 22 simple things you can do to get up to _70 points_ on your project. RELATED ARTICLES Green Rating Systems for Home BuildingGBA Encyclopedia: LEED for HomesWhy Is the U.S. Green Building Council So Out of Touch?It’s 2012 — Do You Know Where Your LEED for Homes Is?New Urbanist Andres Duany Lashes Out at LEEDGreen Building Programs Got Some ’Splainin’ to Do LEED-H Clarifications Raise More Questions Than They AnswerEqual-Opportunity Feather Rufflingcenter_img 1. Build a smaller home/call everything a bedroom. Keeping your house below the neutral score for homes of 1900 SF with three bedrooms will lower the total number of points you need. If your house is big, make sure you have lots of rooms that can be classified as bedrooms to offset the point penalty for larger homes. A bedroom is classified as any room that can be used for sleeping that meets fire and building code requirements. Who needs hallways when you can have more bedrooms?2. Build near transit, stores, schools, etc. Considering that transportation energy is almost always more than site energy, this one gets some real-world results. Points for infill projects , homes built on previously developed land, built near existing water and sewer service and near open space all gain points. Up to 10 points are available for location credits.3. Use less wood. Building with advanced framing techniques is not hard, saves money, makes buildings more efficient, and provides points. Just do it and grab up to 3 points.4. Build a duplex. High density development is tough to do for custom single family homes, but easy for multifamily projects . Build on a 1/7 acre (or smaller) lot and get 2 points. Twenty or more units per acre gets you 4 points.5. Model your building. Get your rater to do an energy model (HERS Rating) on your project early in the process and play around with different options to make it more efficient. You may find that putting a little more insulation and a smaller HVAC system is cheaper and will get you more points. While it’s tough to approach the 0 HERS score that gets you 34 points, a HERS 70 is not that tough and gets you either 9.5 or 13 points, depending on your climate zone.6. Leave out the fireplace — get 2 points. No one really needs one anyway, do they?7. Leave the garage out back. Build a detached garage , add a breezeway if your clients are afraid of getting wet, and get 3 points.8. Get your LEED AP Homes designation, or have someone on your team get their LEED AP Homes designation (regular AP designations don’t qualify) and pick up one easy point.9. Use your Green Rater. You have to put together the durability management checklist anyway, and if you have your rater independently verify it you get 3 points. This may take a little extra work coordinating schedules and providing some photo-documentation, but it gets you a lot of points for the effort.10. Don’t poison bugs. Design and build to keep those pesky termites at bay without poisoning your clients, get up to 2 points.11. Be stingy with outside water use. If you’re putting in irrigation , you get up to 3 points for including some simple water efficiency measures.12. Be stingy with interior water use. Install one efficient showerhead (just one!) per stall, high efficiency toilets and lavatories (all of them) and get 6 points. Doh!13. Insulate the hot water pipes — get a point.14. Use green products and materials. Tracking Environmentally Preferred Products is kind of an administrative nightmare, but you can pick up as many as 8 points for things like finger-jointed studs, fly ash in concrete, PEX pipe, locally sourced products (within 500 miles), no carpet, and low-VOC paints.15. Recycle. If there are companies that recycle construction waste in your area, hire them. You’ll probably save money and pick up as many as 3 points.16. Three words: Automatic Bath Fans. Install timers, motion sensors, or buy fans with auto off or humidistat controls for your bathrooms and pick up a point.17. Upgrade the HVAC filters. You have to put in a minimum of MERV 8 HVAC filters , so why not upgrade to a 10 or 13 and pick up 1 or 2 more points for not much cost or effort.18. Take off your shoes. Install a bench and shelves for shoe storage at the main entry, add one point.19. Make vacuuming easy. Install a central vacuum system, get another point.20. Air out the house for at least 48 hours before occupancy. It’s a good idea and an easy point.21. Vent the soil gasses . If you’re not in a radon risk zone, it’s still a good idea to put in a soil gas vent system and you get to take a point for not much effort.22. Brag about your green-ness. Put up a LEED for Homes sign, stick a few pages on your website about LEED, get an article published, hold four open houses. Pick three and you get a point. These are all good marketing practices and will help you get more business.OK, class, I think I’ve given you enough for you to digest for today. Your assignment is, based on what you just learned, to look at a recent project you either certified, or thought about certifying, and note where you missed some easy points. Now you know how to pick up those points on the next project. Next time we will discuss the really tough credits to get, the secret credits, prerequisites, and how to handle your documentation.*No, that title wasn’t my idea. It was my damned editor’s. But I got paid, and you read the article, right?last_img read more

The Hazards of Cooking With Gas

first_imgCooking with gas lowers indoor air quality and raises a variety of health concerns, researchers at the Lawrence Berkeley National Laboratory report.Scientists found indoor pollution levels in many homes exceeded legal outdoor limits. In an article posted at Indoor Environment Connections, Dr. Brett Singer said, “If these were conditions that were outdoors, the Environmental Protection Agency would be cracking down. But since it’s in people’s homes, there’s no regulation requiring anyone to fix it.“Reducing people’s exposure to pollutants from gas stoves should be a public health priority,” Singer added.Researchers estimated that 60% of California homes where a gas stove was used for cooking at least once a week had indoor pollutant levels exceeding legal outdoor limits. The finding means that millions of people are subjected to levels of nitrogen dioxide, formaldehyde, and carbon monoxide in excess of current standards. Performance of range hoods variedPreviously, Indoor Environment Connections said, researchers found range hoods varied widely in how effectively they remove pollutants. That study focused on seven models ranging in price from $40 to $650, with the “capture efficiency” of the units measured at less than 15% to more than 98%.The hoods typically did a better job of capturing pollutants from the back burners than from the front of the stove. Hoods with grease screens and metal-covered bottoms didn’t do as well as those with open designs.One hood was able to capture more than 80% of the pollutants from the front burners, but it was too loud to allow for normal conversation. That suggested to Singer that manufacturers could do better in their designs.For more information on this topic, see Pollution in the Home: Kitchens Can Produce Hazardous Levels of Indoor Pollutants. Brett Singer’s full report is posted online: A Method to Estimate the Chronic Health Impact of Air Pollutants in U.S. Residences.In a related project, Berkeley Lab researchers concluded the health consequences of poor indoor air quality “are as significant as those from all traffic accidents or infectious diseases in the United States.” Cooking was said to be a major contributor to the problem, not only because of the gas burners but also because of pollutants given off as foods are cooked.last_img read more

NLEX, Blackwater unveil new faces in clash

first_imgSmash hit? Tesla suffers broken glass mishap at launch of new truck PLAY LIST 01:08Smash hit? Tesla suffers broken glass mishap at launch of new truck00:50Trending Articles02:34Google unveils motion-sensing Pixel 401:37Protesters burn down Iran consulate in Najaf01:47Panelo casts doubts on Robredo’s drug war ‘discoveries’01:29Police teams find crossbows, bows in HK university01:35Panelo suggests discounted SEA Games tickets for students02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games NLEX, which bounced back from its first loss in style last week, tries to get another winning streak going and put its retooled roster to the test yet again when the Road Warriors clash with Blackwater in the PBA Governors’ Cup eliminations at Smart Araneta Coliseum on Friday.ADVERTISEMENT Read Next LATEST STORIES Change of heart on the SEAG SEA Games in Calabarzon safe, secure – Solcom chief Don’t miss out on the latest news and information. UPLB exempted from SEA Games class suspension Catriona Gray spends Thanksgiving by preparing meals for people with illnesses MOST READ Flags of SEA Games countries raised at Athletes Village Brace for potentially devastating typhoon approaching PH – NDRRMC WATCH: Streetboys show off slick dance moves in Vhong Navarro’s wedding LOOK: Venues for 2019 SEA Games Game time is 7 p.m. with the Road Warriors hoping to inch closer to the first quarterfinal slot even as Phoenix Petroleum tries to stop the bleeding when it battles Meralco in the 4:15 p.m. game.Cyrus Baguio plays his first game reunited with old mentor Yeng Guiao at NLEX.FEATURED STORIESSPORTSWATCH: Drones light up sky in final leg of SEA Games torch runSPORTSSEA Games: Philippines picks up 1st win in men’s water poloSPORTSMalditas save PH from shutoutBlackwater, meanwhile, will not be easy pickings as the Elite got a much needed shot in the arm the last time up when Henry Walker arrived and led them to their first win.The Bolts, meanwhile, try to regroup after being dealt a first loss by the Road Warriors. View comments Man sworn in as lawyer by judge who sentenced him to prison as a teen 20 years agolast_img read more

Azkals resume Asian Cup bid

first_imgFrontrow holds fun run to raise funds for young cancer patients  Typhoon Kammuri accelerates, gains strength en route to PH MOST READ BSP sees higher prices in November, but expects stronger peso, low rice costs to put up fight Great push for Philippine boxing Brace for potentially devastating typhoon approaching PH – NDRRMC Trending Articles PLAY LIST 00:50Trending Articles02:49World-class track facilities installed at NCC for SEA Games01:30Eriksson’s ‘Azkals’ put Philippines on Asian Cup map01:37Protesters burn down Iran consulate in Najaf01:47Panelo casts doubts on Robredo’s drug war ‘discoveries’01:29Police teams find crossbows, bows in HK university01:35Panelo suggests discounted SEA Games tickets for students02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games Nonong Araneta re-elected as PFF president With Tajikistan hosting Nepal in Dushanbe in the other Group F encounter, the Azkals are hard-pressed to gain maximum points against the Yemenis, who held the Filipinos to a 2-2 draw in Bacolod last Sept. 5.Strife-torn Yemen, two points behind the Philippines, plays its home matches in Doha due to security concerns.FEATURED STORIESSPORTSWATCH: Drones light up sky in final leg of SEA Games torch runSPORTSSEA Games: Philippines picks up 1st win in men’s water poloSPORTSMalditas save PH from shutout“If we tie, we still have two chances to qualify,” said Azkals coach Thomas Dooley. LATEST STORIES Fire hits houses in Mandaluyong City Don’t miss out on the latest news and information. The Philippines tries to inch closer to an AFC Asian Cup berth when it clashes with Yemen on Tuesday in Qatar.Currently on top of Group F with seven points, the Azkals are gunning for their third victory in the qualifying round that will give them the inside track in the race for the two Asian Cup spots at stake in the group.ADVERTISEMENT Kammuri turning to super typhoon less likely but possible — Pagasa LOOK: Loisa Andalio, Ronnie Alonte unwind in Amanpulo for 3rd anniversary Read Next View commentslast_img read more

Toys R Us Canada selects Cineplex Digital Medias Digital Signage and Kiosks

first_img LEAVE A REPLY Cancel replyLog in to leave a comment Advertisement Twitter Login/Register With: “We are very pleased to be working with Toys “R” Us on this exciting and innovative project,” notes Nick Prigioniero, President, Cineplex Digital Media. “We look forward to enhancing the in-store experience by integrating our custom digital technologies into an easy, one-stop-shopping process for their customers.”The installation includes a large feature wall with 2×2- 55″ LCD screens, six 18.5″ digital end caps and four POS integrated kiosks. Cineplex Digital Media will lead all content creation for the kiosks, and provide content management for the digital end caps and feature wall signage.On a mission to revolutionize digital experiences where people work, shop and play, Cineplex Digital Media has made a name for itself in the Out-of-Home, Retail, Financial and Quick Service Restaurant industries by providing strategic, digital display and network solutions for its clients, including Toys “R” Us. CDM’s industry leadership stems from its expertise in offering clients a full-service, end-to-end digital signage solution, including research and creative strategy, content production, installation and technical support, digital asset management, media sales and data analytics. For more information on Cineplex Digital Media, visit CineplexDigitalMedia.com.About CineplexA leading entertainment and media company, Cineplex (TSX: CGX) is a top-tier Canadian brand that operates in the Film Entertainment and Content, Amusement and Leisure, and Media sectors. As Canada’s largest and most innovative film exhibitor, Cineplex welcomes 75 million guests annually through its circuit of 164 theatres across the country. Cineplex also operates successful businesses in digital commerce (CineplexStore.com), food service, alternative programming (Cineplex Events), cinema media (Cineplex Media), digital place-based media (Cineplex Digital Media) and amusement solutions (Player One Amusement Group). It also operates a location based entertainment business through Canada’s newest destination for ‘Eats & Entertainment,’ The Rec Room, and an online eSports platform for competitive and passionate gamers (WorldGaming.com). Additionally, Cineplex is a joint venture partner in SCENE, Canada’s largest entertainment loyalty program.Proudly recognized as having one of the country’s Most Admired Corporate Cultures, Cineplex employs over 13,000 people in its offices across Canada and the United States. To learn more visit Cineplex.com or download the Cineplex App. Advertisementcenter_img Cineplex (CNW Group/Cineplex) Facebook Advertisement TORONTO, July 25, 2017 – Today Cineplex Digital Media (“CDM”) announced that it has been selected to install an in-store digital signage and kiosk network for Toys “R” Us’ new concept store. Located in Langley, British Columbia, Cineplex Digital Media’s innovative technologies play a pivotal role in the deployment of the new store concept.“Our Langley store is the evolution of our digital future,” says Clint Gaudry, Vice President, Marketing & Store Planning at Toys “R” Us. “The new integrated network elevates the shopping experience and makes it easier for customers to locate the products they are looking for, gain in depth information and make their purchases directly from a number of kiosks located throughout the store.”Toys “R” Us will deploy an ‘endless aisle’ solution where customers can use the kiosks to browse not only in-stock items, but the brand’s entire offering. Powered by Cineplex Digital Media technology, the kiosks will feature videos and provide comprehensive product information to shoppers before making their purchase. Then by selecting “Get it now!” customers can complete their transaction right at the kiosk and pick up their purchase at the front of the store or have it shipped directly to their home.last_img read more

Shopping while brown InFocus tackles racial profiling

first_imgInFocusRacial profiling can come in many forms. Have you ever been followed by store staff while shopping? Do you seem to get served differently in restaurants or in stores? Does it happen regularly?  Has you changed the way you act in stores because of this?If you said you yes, you may be the victim of racial profiling.  This week, Host Melissa Ridgen put Shopping While Brown InFocus.What exactly does it mean to be racially profiled in store?Tomee Sojourner-Campbell is a Master of Laws candidate at Osgoode Hall Law School at York University and founder of Prevent CRP (Consumer Racial Profiling).She has been working for years to bring awareness of this problem and works with businesses to prevent it.“Consumer racial profiling is when you walk into a store and someone is following you and it’s the assumption that the person they see in the store or going into the bank, usually racialized Black or Indigenous is going to do something wrong,” she said. “Because it’s often, not only the assumption that somebody is a threat but its in the way you get treated.”“It’s not just about people assuming that you’re going to steal but its about the lack of context, the lack of respect that’s afforded to the individual that’s come into the store to purchase an item.”Amy Anderson is a Winnipeg resident who has had enough of these experiences.  She told Ridgen that she recently had an unpleasant experience in a local restaurant that is frequented by many Indigenous patrons.Anderson, along with her parents were ignored after they sat down.  They had to ask multiple times to have someone take their drink order.  When they finally got to order their food, they waited for an hour for it come – and once it arrived, she found a pubic hair in her dish and her mother’s chicken wings were undercooked.“My parents have been at this hotel numerous times and it seems like it’s the same service, the same treatment and it just so happened that both my mom and my food was tampered with. How could that be a coincidence?” Anderson said.“It did feel discriminatory towards us.”last_img read more

10 SportsRelated Jobs Black Children Should Look Into Instead

Audio and Video Equipment SpecialistSports teams rely heavily on being able to review footage of games, individual players, schemes, tendencies, etc. Teams always seek people skilled at editing videos and breaking them down for easy, specific viewing. It also can be an entrée into coaching. Mike Brown, who coached the NBA’s Cleveland Cavaliers twice and Los Angeles Lakers, started as a video coordinator.Public Address AnnouncerHave an appealing voice, read fluidly and have command of an audience? Working courtside or in the press box as the PA announcer could be for you. It’s a coveted job and an important one that puts you right in the middle of the action. read more

Wagner blames red card for Huddersfields loss

first_imgHuddersfield Town manager David Wagner insists the red card picked up by Christopher Schindler played a significant role in his team’s loss to Burnley.The Terriers hosted fellow strugglers Burnley at the John Smith Stadium on Wednesday night looking for their first Premier League victory in 10 games.Steve Mounie gave the home side the lead just past the half-hour mark with his first league goal of the season, but Sean Dyche’s men leveled just before the break from a Chris Wood strike.Things went from bad to worse for Huddersfield when Schindler was giving his marching orders four minutes before halftime, leaving Wagner’s men to play the entire second half with 10 men.Ashley Barnes 74th minute goal ensured Burnley took home all three points leaving Huddersfield rooted to the bottom of the league table.Danny CowleyCowley explains why he changed his mind about Huddersfield Manuel R. Medina – September 9, 2019 Last week Danny Cowley rejected the chance to coach Huddersfield Town in the English Championship, but today he accepted saying it was a good opportunity.“The commitment, effort and attitude which the players have shown was absolute”, Wagner said, according to Sky Sports.“They fought but unfortunately playing more than one half [with 10 men] is very difficult to deal with.”“We took the lead and scored our first goal from a striker. I have seen a lot of good things today but obviously we weren’t able to keep the tempo and speed as high as when we played 11 v 11.”last_img read more

EDUCATION MINISTRY CONFIDENT OF ACHIEVING LITERACY TARGET

first_imgFacebook Twitter Google+LinkedInPinterestWhatsAppKINGSTON, Jan. 19 (JIS): The Ministry of Education is expressing confidence in attaining its goal of85 per cent of students in the grade four age cohort achieving mastery of literacy in 2015.An optimistic Portfolio Minister, the Hon. Rev. Ronald Thwaites, notes that the country is now 7.6 per cent away from achieving this target.“The final measurement will be made at this year’s sitting of the Grade Four Literacy Test,” he said.The Minister was speaking at a meeting with senior journalists at the Alhambra Inn Hotel in St. Andrew recently.Rev. Thwaites pointed out that when the 15 per cent of students who suffer from learning disabilities are accounted for, 85 per cent translates to 100 per cent of the educable cohort.According to National Literacy Co-ordinator, Dr. André Hill, the Ministry will do everything it possibly can in the next few months to maximise as much as possible students’ outcomes in the 2015 Grade Four Literacy Test.He pointed to the deployment of 66 reading coaches across the island to provide direct support to 420 primary schools. Each will work with approximately seven schools. “They will be particularly working with the struggling readers in grade four, providing clinical attention to these students as well as pedagogical support for classroom teachers, in addition to extending further support to the parents in schools that have registered low achievement at grade four over the last three years,” he said.Dr. Hill contended that if the Ministry gets support from the community in addition to what the Ministry is now extending to the school system, “we are certain the outcomes, certainly for this year, will take us very close, if not actually to the 85 per cent.” Meanwhile, the Minister reiterated the importance of the role parents, home life and community have in helping to achieve the target. He noted for instance, that encouraging children to read in Sunday school greatly helps the literacy levels of students.He further urged parents, even if they are not literate themselves, to encourage their children to read.The Minister informed that at the 2014 sitting of the grade four literacy test,77.4 per cent of the age cohort achieved the acceptable standard of mastery in literacy, which represented a 30 per cent increase for the 10-year period – 2004 to 2014. He noted that the improvement in literacy has been the result of the combined efforts of the Ministry’s National Literacy Team and dedicated teachers. “In addition, the country is indebted to the United States Agency for International Development (USAID) for its support in improving literacy outcomes,” he said. In terms of the numeracy test, Rev. Thwaites informed that 58 per cent of students who sat the Grade Four Test last year attained mastery, a marginal decline of 1.4 per cent over the previous year.“But, there has been a 20 per cent improvement for the past five years, moving from a low of 38 per cent in 2010,” he said.The Minister said that using literacy as a benchmark, the Ministry is pleased with the progress the country has made so far.The Grade Four Literacy and numeracy tests are administered to children to determine their literacy and numeracy levels at grade four, in keeping with international requirements and standards. Facebook Twitter Google+LinkedInPinterestWhatsApp Jamaica’s Senate Begins debate on National Identification and Registration Bill Related Items:jamaica, ministry of education, Ronald Thwaites Recommended for you Bahamas DPM Turnquest, as IDB Governor, Talks Technology and Climate Change Resilience at IDB Conclave Two boys die, bicycle and van collide in St. Catherine, Jamaicalast_img read more